Proteostasis of Huntingtin in Health and Disease.
Koyuncu, Seda; Fatima, Azra; Gutierrez-Garcia, Ricardo; Vilchez, David.
Int J Mol Sci
; 18(7)2017 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-28753941
An Expanded CAG Repeat in Huntingtin Causes +1 Frameshifting.
Conformation Polymorphism of Polyglutamine Proteins.
Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation.
Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease.
Non-cell Autonomous Maintenance of Proteostasis by Molecular Chaperones and Its Molecular Mechanism.
Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.
The cryo-electron microscopy structure of huntingtin.
Proteostatic Tactics in the Strategy of Sterol Regulation.
Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells.
MicroRNA-27a reduces mutant hutingtin aggregation in an in vitro model of Huntington's disease.