Synthesis and anti-tumor activity of EF24 analogues as IKKß inhibitors.
Jin, Rong; Chen, Qiuxiang; Yao, Song; Bai, Encheng; Fu, Weitao; Wang, Ledan; Wang, Jiabing; Du, Xiaojing; Wei, Tao; Xu, Haineng; Jiang, Chengxi; Qiu, Peihong; Wu, Jianzhang; Li, Wulan; Liang, Guang.
Eur J Med Chem
; 144: 218-228, 2018 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-29351887
A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies.
Design, synthesis, and biological evaluation of novel and analogs as potential IκB kinase ß inhibitors for the treatment of pancreatic cancer.
IKKß promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
The small-molecule inhibitor selectivity between IKKα and IKKß kinases in NF-κB signaling pathway.
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation.
Synthesis and evaluation of novel aza-caged Garcinia xanthones.
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKÉ supports the anabolic demands of dendritic cell activation.
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells.