Clonal CD4<sup>+</sup> T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation.
Cohn, Lillian B; da Silva, Israel T; Valieris, Renan; Huang, Amy S; Lorenzi, Julio C C; Cohen, Yehuda Z; Pai, Joy A; Butler, Allison L; Caskey, Marina; Jankovic, Mila; Nussenzweig, Michel C.
; 24(5): 604-609, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29686423
Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir.
Genetically Intact but Functionally Impaired HIV-1 Env Glycoproteins in the T-Cell Reservoir.
HIV-1 Infection of Primary CD4<sup>+</sup> T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements.
Multiple Origins of Virus Persistence during Natural Control of HIV Infection.
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.
Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane.
Single-molecule techniques to quantify and genetically characterise persistent HIV.
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.
HIV-1 integration landscape during latent and active infection.
Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications.