The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region.
Pujols, Jordi; Santos, Jaime; Pallarès, Irantzu; Ventura, Salvador.
Int J Mol Sci
; 19(5)2018 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-29734798
Remembering the Past: A New Form of Protein-Based Inheritance.
Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits.
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.
Hsp12 is an intrinsically unstructured stress protein that folds upon membrane association and modulates membrane function.
The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation.
CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation.
Mechanistic Insights into Hsp104 Potentiation.
Disaggregases, molecular chaperones that resolubilize protein aggregates.
Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution.
A systematic survey identifies prions and illuminates sequence features of prionogenic proteins.