p19-Targeting ILP Protein Blockers of IL-23/Th-17 Pro-Inflammatory Axis Displayed on Engineered Bacteria of Food Origin.
Skrlec, Katja; Zadravec, Petra; Hlavnicková, Marie; Kuchar, Milan; Vanková, Lucie; Petroková, Hana; Krízová, Lucie; Cerný, Jirí; Berlec, Ales; Malý, Petr.
Int J Mol Sci
; 19(7)2018 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-29966384
Expanding the recombinant protein quality in Lactococcus lactis.
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The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP.
Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity.
Packaging protein drugs as bacterial inclusion bodies for therapeutic applications.