The distinct role and regulatory mechanism of IL-17 and IFN-Î³ in the initiation and development of plaque vs guttate psoriasis.
Yan, Kexiang; Han, Ling; Deng, Hui; Fang, Xu; Zhang, Zhenghua; Huang, Guiqin; Zheng, Zhi Zhong; Huang, Qiong; Xu, Jinhua.
J Dermatol Sci
; 92(1): 106-113, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30072243
Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis.
Circulating T-helper 17 cells and associated cytokines in psoriasis.
Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis.
Characterization of Th17 and FoxP3(+) Treg Cells in Paediatric Psoriasis Patients.
Psoriasis Targeted Therapy: Characterization of Interleukin 17A Expression in Subtypes of Psoriasis.
Foxp3+ regulatory T cells and related cytokines differentially expressed in plaque vs. guttate psoriasis vulgaris.
MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis.
ß-Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis.
IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells.
Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity.