CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.
Yu, Lei; Yang, Fei; Zhang, Fanghui; Guo, Danfeng; Li, Ling; Wang, Xian; Liang, Tingbo; Wang, Jianli; Cai, Zhijian; Jin, Hongchuan.
Cell Death Dis
; 9(9): 905, 2018 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-30185773
Tr1 cells in the neat sighting-pole
Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive.
Regulatory B10 cell development and function.
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy.
Regulatory T cells inhibit acute IFN-Î³ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10.
Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.
B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
An unexpected counter-regulatory role of IL-10 in B-lymphocyte-mediated transplantation tolerance.
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.