Design, synthesis, and evaluation of chalcone analogues incorporate α,ß-Unsaturated ketone functionality as anti-lung cancer agents via evoking ROS to induce pyroptosis.
Zhu, Min; Wang, Jiabing; Xie, Jingwen; Chen, Liping; Wei, Xiaoyan; Jiang, Xing; Bao, Miao; Qiu, Yanyi; Chen, Qian; Li, Wulan; Jiang, Chengxi; Zhou, Xiaoou; Jiang, Liping; Qiu, Peihong; Wu, Jianzhang.
Eur J Med Chem
; 157: 1395-1405, 2018 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-30196062
SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs.
Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors.
Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.
Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells.
Synthesis of some quinolinyl chalcone analogues and investigation of their anticancer and synergistic anticancer effect with doxorubicin.
Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives.
Opening or closing the lock? When reactivity is the key to biological activity.
Novel carbapenem chalcone derivatives: synthesis, cytotoxicity and molecular docking studies.
Chalcone: A Privileged Structure in Medicinal Chemistry.
Synthesis and evaluation of modified chalcone based p53 stabilizing agents.