Exploiting novel tailored immunotherapies of type 1 diabetes: Short interfering RNA delivered by cationic liposomes enables efficient down-regulation of variant PTPN22 gene in T lymphocytes.
Pellegrino, Marsha; Ceccacci, Francesca; Petrini, Stefania; Cappa, Marco; Mancini, Giovanna; Fierabracci, Alessandra.
; 2018 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-30439564
Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes.
Small interfering RNA (siRNA)-mediated knockdown of Notch1 suppresses tumor growth and enhances the effect of IL-2 immunotherapy in malignant melanoma.