CFTR structure, stability, function and regulation.
Meng, Xin; Clews, Jack; Ciuta, Anca D; Martin, Eleanor R; Ford, Robert C.
; 2019 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-30738013
Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator.
STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL.
Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function.
Conformational Changes of CFTR upon Phosphorylation and ATP Binding.
Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.
Functional architecture of the CFTR chloride channel.
Molecular Dynamics Flexible Fitting Simulations Identify New Models of the Closed State of the Cystic Fibrosis Transmembrane Conductance Regulator Protein.
Molecular models of the open and closed states of the whole human CFTR protein.
Timing of CFTR pore opening and structure of its transition state.
How Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).