Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).

Watterson, Scott H; Liu, Qingjie; Beaudoin Bertrand, Myra; Batt, Douglas G; Li, Ling; Pattoli, Mark A; Skala, Stacey; Cheng, Lihong; Obermeier, Mary T; Moore, Robin; Yang, Zheng; Vickery, Rodney; Elzinga, Paul A; Discenza, Lorell; D'Arienzo, Celia; Gillooly, Kathleen M; Taylor, Tracy L; Pulicicchio, Claudine; Zhang, Yifan; Heimrich, Elizabeth; McIntyre, Kim W; Ruan, Qian; Westhouse, Richard A; Catlett, Ian M; Zheng, Naiyu; Chaudhry, Charu; Dai, Jun; Galella, Michael A; Tebben, Andrew J; Pokross, Matt; Li, Jianqing; Zhao, Rulin; Smith, Daniel; Rampulla, Richard; Allentoff, Alban; Wallace, Michael A; Mathur, Arvind; Salter-Cid, Luisa; Macor, John E; Carter, Percy H; Fura, Aberra; Burke, James R; Tino, Joseph A.
J Med Chem; 62(7): 3228-3250, 2019 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-30893553