The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease.
Raulin, Ana-Caroline; Kraft, Lucas; Al-Hilaly, Youssra K; Xue, Wei-Feng; McGeehan, John E; Atack, John R; Serpell, Louise.
J Mol Biol
; 431(12): 2248-2265, 2019 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-31051176
Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E.
A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions.
Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry.
APOE Îµ4/Îµ4 diminishes neurotrophic function of human iPSC-derived astrocytes.
Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease.
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes.
Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.
ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.
Molecular Mechanisms of the R61T Mutation in Apolipoprotein E4: A Dynamic Rescue.
Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls.