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Effect of Lactation on myocardial vulnerability to ischemic insult in rats / Efeito da Lactação sobre a Vulnerabilidade do Miocárdio ao Insulto Isquêmico em Ratas
Askari, Sahar; Imani, Alireza; Sadeghipour, Hamidreza; Faghihi, Mahdieh; Edalatyzadeh, Zohreh; Choopani, Samira; Karimi, Nasser; Fatima, Sulail.
Affiliation
  • Askari, Sahar; Tehran University of Medical Sciences. Tehran. IR
  • Imani, Alireza; Tehran University of Medical Sciences. Tehran. IR
  • Sadeghipour, Hamidreza; Tehran University of Medical Sciences. Tehran. IR
  • Faghihi, Mahdieh; Tehran University of Medical Sciences. Tehran. IR
  • Edalatyzadeh, Zohreh; Tehran University of Medical Sciences. Tehran. IR
  • Choopani, Samira; Tehran University of Medical Sciences. Tehran. IR
  • Karimi, Nasser; Tehran University of Medical Sciences. Tehran. IR
  • Fatima, Sulail; Tehran University of Medical Sciences. Tehran. IR
Arq. bras. cardiol ; 108(5): 443-451, May 2017. tab, graf
Article in English | LILACS | ID: biblio-838732
Responsible library: BR1.1
ABSTRACT
Abstract

Background:

Cardiovascular diseases are the leading cause of mortality and long-term disability worldwide. Various studies have suggested a protective effect of lactation in reducing the risk of cardiovascular diseases.

Objective:

This study was designed to assess the effects of pregnancy and lactation on the vulnerability of the myocardium to an ischemic insult.

Methods:

Eighteen female rats were randomly divided into three groups ischemia-reperfusion (IR), in which the hearts of virgin rats underwent IR (n = 6); lactating, in which the rats nursed their pups for 3 weeks and the maternal hearts were then submitted to IR (n = 6); and non-lactating, in which the pups were separated after birth and the maternal hearts were submitted to IR (n = 6). Outcome measures included heart rate (HR), left ventricular developed pressure (LVDP), rate pressure product (RPP), ratio of the infarct size to the area at risk (IS/AAR %), and ventricular arrhythmias - premature ventricular contraction (PVC) and ventricular tachycardia (VT).

Results:

The IS/AAR was markedly decreased in the lactating group when compared with the non-lactating group (13.2 ± 2.5 versus 39.7 ± 3.5, p < 0.001) and the IR group (13.2 ± 2.5 versus 34.0 ± 4.7, p < 0.05). The evaluation of IR-induced ventricular arrhythmias indicated that the number of compound PVCs during ischemia, and the number and duration of VTs during ischemia and in the first 5 minutes of reperfusion in the non-lactating group were significantly (p < 0.05) higher than those in the lactating and IR groups.

Conclusion:

Lactation induced early-onset cardioprotective effects, while rats that were not allowed to nurse their pups were more susceptible to myocardial IR injury.
RESUMO
Resumo Fundamento As doenças cardiovasculares são a principal causa de mortalidade e invalidez a longo prazo a nível mundial. Diversos estudos têm sugerido um efeito protetor da lactação na redução do risco para doenças cardiovasculares.

Objetivo:

Este estudo foi desenvolvido para avaliar os efeitos da gestação e da lactação sobre a vulnerabilidade do miocárdio ao insulto isquêmico.

Métodos:

Dezoito ratas foram divididas aleatoriamente em três grupos isquemia-reperfusão (IR), no qual os corações de ratas virgens foram submetidos à IR (n = 6); lactantes, no qual as ratas amamentaram seus filhotes por 3 semanas e os corações maternos foram, em seguida, submetidos à IR (n = 6); e não lactantes, no qual os filhotes foram separados após o nascimento e os corações maternos foram submetidos à IR (n = 6). As medidas de desfecho incluíram frequência cardíaca (FC), pressão desenvolvida no ventrículo esquerdo (PDVE), duplo produto (DP), razão do tamanho do infarto sobre a área sob risco (TI/ASR %) e arritmias ventriculares - contração ventricular prematura (CVP) e taquicardia ventricular (TV).

Resultados:

O TI/ASR foi substancialmente menor no grupo de lactantes quando comparado ao grupo de não lactantes (13,2 ± 2,5 versus 39,7 ± 3,5, p < 0,001) e ao grupo IR (13,2 ± 2,5 versus 34,0 ± 4,7, p < 0,05). A avaliação das arritmias ventriculares induzidas pela IR indicou que o número de CVPs compostas na isquemia, e o número e a duração das TVs na isquemia e nos primeiros 5 minutos de reperfusão no grupo de não lactantes foram significativamente (p < 0,05) mais elevados do que os encontrados nos grupos IR e de lactantes.

Conclusão:

A lactação induziu o aparecimento precoce de efeitos cardioprotetores, enquanto ratas que não foram permitidas a amamentar seus filhotes se mostraram mais suscetíveis à lesão miocárdica por IR.
Subject(s)


Full text: Available Collection: International databases Health context: SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases Health problem: Cardiovascular Disease / Ischemic Heart Disease / Other circulatory Diseases Database: LILACS Main subject: Lactation / Myocardial Reperfusion Injury / Myocardial Ischemia / Myocardial Infarction Limits: Animals / Pregnancy Language: English Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2017 Document type: Article Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR

Full text: Available Collection: International databases Health context: SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases Health problem: Cardiovascular Disease / Ischemic Heart Disease / Other circulatory Diseases Database: LILACS Main subject: Lactation / Myocardial Reperfusion Injury / Myocardial Ischemia / Myocardial Infarction Limits: Animals / Pregnancy Language: English Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2017 Document type: Article Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR
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