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The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data
Gouvêa, Eduardo S; Santos Filho, Airton F; Ota, Vanessa K; Mrad, Vinicius; Gadelha, Ary; Bressan, Rodrigo A; Cordeiro, Quirino; Belangero, Sintia I.
Affiliation
  • Gouvêa, Eduardo S; Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo. BR
  • Santos Filho, Airton F; Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo. BR
  • Ota, Vanessa K; Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo. BR
  • Mrad, Vinicius; Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo. BR
  • Gadelha, Ary; Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo. BR
  • Bressan, Rodrigo A; Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo. BR
  • Cordeiro, Quirino; Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo. BR
  • Belangero, Sintia I; Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 39(2): 160-171, Apr.-June 2017. tab, graf
Article in English | LILACS | ID: biblio-844185
Responsible library: BR1.1
ABSTRACT

Objective:

Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (and its subphenotypes) and polymorphisms in the CNR1 gene, which encodes cannabinoid receptors classically implicated in schizophrenia pathophysiology, as well as to present unpublished results of an association study in a Brazilian population.

Methods:

Two reviewers independently searched for eligible studies and extracted outcome data using a structured form. Papers were retrieved from PubMed and ISI Web of Knowledge using the search term schizophrenia in combination with CNR1 or CB1 or cannabinoid receptor. Twenty-four articles met our inclusion criteria. We additionally present data from a study of our own comparing 182 patients with schizophrenia and 244 healthy controls.

Results:

No consistent evidence is demonstrated.

Conclusion:

Some seemingly positive association studies stress the need for further investigations of the possible role of endocannabinoid genetics in schizophrenia.
Subject(s)


Full text: Available Collection: International databases Database: LILACS Main subject: Schizophrenia / Polymorphism, Single Nucleotide / Receptor, Cannabinoid, CB1 Type of study: Observational study / Prognostic study / Risk factors / Systematic review Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2017 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR

Full text: Available Collection: International databases Database: LILACS Main subject: Schizophrenia / Polymorphism, Single Nucleotide / Receptor, Cannabinoid, CB1 Type of study: Observational study / Prognostic study / Risk factors / Systematic review Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2017 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR
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