Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
Clin. biomed. res
; 37(2): 87-90, 2017. tab
Article
in English
| LILACS
| ID: biblio-847958
Responsible library:
BR18.1
Localization: BR18.1
ABSTRACT
Biliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient's genetic constitution. This study aimed to analyze information concerning environmental risk factors associated with BA in southern Brazil. A case-control study with mothers of patients with BA and mothers of patients with cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition to environmental risk factors during the periconceptional and gestational (second and third trimesters) periods. Mothers of BA patients had smoked during pregnancy more frequently in comparison with the mothers of CF patients, but no significant difference was found in a multivariate analysis. There was no between group difference in terms of seasonality, but the multivariate analysis showed a significant difference within the BA group between date of conception in winter compared to other seasons. In conclusion, smoking during pregnancy seemed to increase the risk of BA while date of conception in winter decreased it (AU)
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Biliary Atresia
/
Risk Factors
/
Maternal Exposure
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Clin. biomed. res
Journal subject:
Medicine
Year:
2017
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital de Clínicas de Porto Alegre/BR
/
Universidade Federal do Rio Grande do Sul/BR