Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
Acta cir. bras
; 34(1): e20190010000009, 2019. tab, graf
Article
in En
| LILACS
| ID: biblio-983686
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation.Methods:
A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during follow-up. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests.Results:
Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956).Conclusion:
The results demonstrated that patients who did not use UDCA showed a 24.4-fold greater probability of developing cholelithiasis.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Postoperative Complications
/
Ursodeoxycholic Acid
/
Obesity, Morbid
/
Cholagogues and Choleretics
/
Gastric Bypass
/
Gallstones
Type of study:
Clinical_trials
/
Etiology_studies
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2019
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil