Risk factors of local relapse in breast cancer: the importance of age
Clin. transl. oncol. (Print)
; 9(2): 110-116, feb. 2007. tab, ilus
Article
in English
| IBECS
| ID: ibc-123276
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
PURPOSE:
The objective of the present analysis is to know what risk factors affect local relapse in breast cancer. METHODS AND MATERIALS A total of 1165 patients diagnosed with early breast cancer were included. Boost dose was modulated in the presence of risk factors. Patients with one risk factor received a boost of 10 Gy, while 20 Gy was administered in those with two risk factors.RESULTS:
Median follow-up was of 60 months. Mean age of patients was 56.7+/-10.8 years. Local risk factors were present in 82.8% of patients. The probability of remaining free of local recurrence at 5 and 10 years is 97.7% (CI 95% 96.7-98.7) and 94.5% (CI 95% 92.1-96.9). Only age showed an impact in local relapse on multivariate analysis. Patients 40 years or younger had a relative risk of local relapse of 5.27 and patients 41-50 of 3.7 with respect to patients older than 50 years.CONCLUSION:
Patients 40 years or younger have a higher risk of local failure than older patients. Other risk factors such as tumour size, intraductal carcinoma or margin status could be masked by an increase of radiation dose (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Breast Neoplasms
/
Adenocarcinoma
/
Neoplasm Recurrence, Local
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2007
Document type:
Article
Institution/Affiliation country:
Universitat Pompeu Fabra/Spain