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Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptors: how to make a dream come true
Lannes-Vieira, Joseli; Silverio, Jaline Coutinho; Pereira, Isabela Resende; Vinagre, Nathália Ferreira; Carvalho, Cristiano Marcelo Espinola; Paiva, Cláudia Neto; Silva, Andréa Alice da.
Affiliation
  • Lannes-Vieira, Joseli; Fiocruz. Programa Integrado de Doença de Chagas.
  • Silverio, Jaline Coutinho; Fiocruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro. BR
  • Pereira, Isabela Resende; Fiocruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro. BR
  • Vinagre, Nathália Ferreira; Fiocruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro. BR
  • Carvalho, Cristiano Marcelo Espinola; Fiocruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro. BR
  • Paiva, Cláudia Neto; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Prof. Paulo de Góes. Departamento de Imunologia. Rio de Janeiro. BR
  • Silva, Andréa Alice da; Universidade Federal Fluminense. Departamento de Patologia. Niterói. BR
Mem. Inst. Oswaldo Cruz ; 104(supl.1): 226-235, July 2009. ilus, graf
Article in English | LILACS | ID: lil-520883
Responsible library: BR1.1
ABSTRACT
One hundred years ago, Carlos Chagas discovered a new disease, the American trypanosomiasis. Chagas and co-workers later characterised the disease's common manifestation, chronic cardiomyopathy, and suggested that parasitic persistence coupled with inflammation was the key underlying pathogenic mechanism. Better comprehension of the molecular mechanisms leading to clinical heart afflictions is a prerequisite to developing new therapies that ameliorate inflammation and improve heart function without hampering parasite control. Here, we review recent data showing that distinct cell adhesion molecules, chemokines and chemokine receptors participate in anti-parasite immunity and/or detrimental leukocyte trafficking to the heart. Moreover, we offer evidence that CC-chemokine receptors may be attractive therapeutic targets aiming to regain homeostatic balance in parasite/host interaction thereby improving prognosis, supporting that it is becoming a non-phantasious proposal.
Subject(s)

Full text: Available Collection: International databases Health context: Neglected Diseases Health problem: Zoonoses Database: LILACS Main subject: Trypanosoma cruzi / Cell Adhesion Molecules / Chagas Cardiomyopathy / Receptors, Chemokine / Myocarditis Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2009 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR / Universidade Federal Fluminense/BR / Universidade Federal do Rio de Janeiro/BR
Full text: Available Collection: International databases Health context: Neglected Diseases Health problem: Zoonoses Database: LILACS Main subject: Trypanosoma cruzi / Cell Adhesion Molecules / Chagas Cardiomyopathy / Receptors, Chemokine / Myocarditis Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2009 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR / Universidade Federal Fluminense/BR / Universidade Federal do Rio de Janeiro/BR
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