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Immunological and parasitological parameters after treatment with dexamethasone in murine Schistosoma mansoni
Aly, Ibrahim RB; Hendawy, Mohamed A; Ali, Eman; Hassan, Eman; Nosseir, Mona MF.
Affiliation
  • Aly, Ibrahim RB; s.af
  • Hendawy, Mohamed A; s.af
  • Ali, Eman; s.af
  • Hassan, Eman; s.af
  • Nosseir, Mona MF; s.af
Mem. Inst. Oswaldo Cruz ; 105(6): 729-735, Sept. 2010. tab
Article in En | LILACS | ID: lil-560655
Responsible library: BR1.1
ABSTRACT
This work aimed to evaluate the effect of diphenyl dimethyl bicarboxylate (DDB) and dexamethasone alone and in combination with praziquantel on various parasitological, immunological and pathological parameters reflecting disease severity and morbidity in murine schistosomiasis. DDB and dexamethasone had no effect on worm burden but altered tissue egg distribution. This indicates that, under the schedule used, neither drug interfered with the development of adult worms or oviposition, but both can modulate liver pathology. Dexamethasone resulted in a greater reduction in granuloma size than did DDB. Dexamethasone-treated mice also showed lower levels of serum gamma interferon (IFN-γ), interleukin-12 (IL-12) and IL-4, together with higher IL-10 levels, than infected untreated control animals. These data suggest that dexamethasone is a convenient and promising coadjuvant agent that results in decreased morbidity in murine schistosomiasis.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Praziquantel / Schistosomiasis mansoni / Dexamethasone / Adjuvants, Immunologic / Dioxoles / Glucocorticoids / Anthelmintics Limits: Animals Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2010 Document type: Article Country of publication: Brazil
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Praziquantel / Schistosomiasis mansoni / Dexamethasone / Adjuvants, Immunologic / Dioxoles / Glucocorticoids / Anthelmintics Limits: Animals Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2010 Document type: Article Country of publication: Brazil