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¿Pensar en hepatitis autoinmune precozmente evita la cirrosis? / Does early autoimmune hepatitis diagnose prevent from cirrhosis?
Buttó, Jenny; Delgado, María; Córdoba, Keila; Sanabria, Ana; Figuera, Zulimar; García, Ysmelia; López, Carmen E.
Affiliation
  • Buttó, Jenny; s.af
  • Delgado, María; s.af
  • Córdoba, Keila; s.af
  • Sanabria, Ana; s.af
  • Figuera, Zulimar; s.af
  • García, Ysmelia; s.af
  • López, Carmen E; Hospital de Niños J M de Los Ríos. Servicio de Gastroenterología Pediátrica. Caracas. VE
GEN ; 66(1): 11-14, mar. 2012. tab
Article in Spanish | LILACS | ID: lil-664187
Responsible library: VE1.1
RESUMEN
La hepatitis autoinmune (HAI) es una hepatopatía inflamatoria crónica y progresiva, que afecta predominantemente al sexo femenino y se caracteriza por la presencia de autoanticuerpos, elevación de aminotransferasas e hipergammaglobulinemia. Evoluciona rápidamente a cirrosis en pacientes no tratados, por lo que su diagnóstico precoz es indispensable. El propósito de este estudio es evaluar el tiempo promedio entre el inicio de los síntomas y el diagnóstico, así como su correlación con la presencia de cirrosis. Se realizó un estudio analítico, retrospectivo, no experimental. Se revisaron las historias clínicas de 51 pacientes que acudieron a la consulta de gastroenterología del hospital de niños J.M. de los Ríos desde abril de 1996 hasta septiembre de 2010 diagnosticados de HAI según criterios clínicos, serológicos e histológicos. Se excluyeron 3 pacientes por presentar patologías asociadas o estar recibiendo tratamiento inmunosupresor previo. La edad varió entre 2 y 15 años (media 8,3±3,2 DE); prevaleciendo el sexo femenino (72,9%). La clínica predominante fue ictericia (81,3%), coluria (47,9%) y dolor abdominal (39,5%). El diagnóstico se realizó en promedio 8,4 ± 7,3 meses luego del inicio de los síntomas. 50% se diagnosticó en los primeros 6 meses, de éstos 54,2% presentó cirrosis y 33,3% fibrosis. La HAI debe considerarse en pacientes pediátricos con clínica de hepatopatía inflamatoria a fin de realizar un diagnóstico oportuno y precoz debido a su rápida evolución a cirrosis
ABSTRACT
Autoimmune hepatitis (HAI) is a progressive chronic inflammatory hepatopathy with higher prevalence in females characterized by autoantibodies presence, elevation of aminotransferases and hipergammaglobulinemia. Another important characteristic is that it can develop into a rapid cirrhosis, so early diagnosis is vital. The purpose of our study is to evaluate the time spent between initial symptoms and final diagnosis, and it relation with the presence of cirrhosis. An analytic, retrospective non experimental study was performed. We reviewed the clinical records of 51 patients from April 1996 to September 2010 who attended the consultation of gastroenterology in the J. M. de los Ríos Children's Hospital with the diagnose of HAI according to clinical criteria, serological and histological. We excluded 3 patients for two reasons. 1. They were presenting associated pathologies 2. They were receiving immunosuppressive treatment. The ages vary from 2 to 15 years old (mean 8.3±3.2 ED); female prevail with (72.9%). The predominant symptoms were jaundice (81.3%), coluria (47.9%) and abdominal pain (39.5%). The diagnosis was made on average 8.4 ± 7.3 months after the beginning of the symptoms. 50% were diagnosed in the first 6 months, from these 54.2% presented with cirrhosis and 33,3% with fibrosis. HAI must be considered in pediatric patients with inflammatory hepatopathy clinical history in order to make an early and opportune diagnosis due to its rapid evolution to cirrhosis
Subject(s)

Full text: Available Collection: International databases Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: LILACS Main subject: Hepatitis, Autoimmune / Liver Cirrhosis / Liver Diseases Type of study: Diagnostic study / Evaluation study / Risk factors / Screening study Limits: Child / Child, preschool Language: Spanish Journal: GEN Year: 2012 Document type: Article Affiliation country: Venezuela Institution/Affiliation country: Hospital de Niños J M de Los Ríos/VE
Full text: Available Collection: International databases Health context: SDG3 - Health and Well-Being Health problem: Target 3.3: End transmission of communicable diseases Database: LILACS Main subject: Hepatitis, Autoimmune / Liver Cirrhosis / Liver Diseases Type of study: Diagnostic study / Evaluation study / Risk factors / Screening study Limits: Child / Child, preschool Language: Spanish Journal: GEN Year: 2012 Document type: Article Affiliation country: Venezuela Institution/Affiliation country: Hospital de Niños J M de Los Ríos/VE
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