Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil
Mem. Inst. Oswaldo Cruz
; 108(3): 392-394, maio 2013.
Article
in English
| LILACS
| ID: lil-676978
Responsible library:
BR1.1
ABSTRACT
The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Antiviral Agents
/
Drug Resistance, Viral
/
Influenza A Virus, H1N1 Subtype
/
Oseltamivir
/
Mutation
/
Neuraminidase
Type of study:
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2013
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Luterana do Brasil/BR