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Tissue distribution of residual antimony in rats treated with multiple doses of meglumine antimoniate
Coelho, Deise Riba; Miranda, Elaine Silva; Saint?Pierre, Tatiana Dillenburg; Paumgartten, Francisco José Roma.
Affiliation
  • Coelho, Deise Riba; Escola Nacional de Saúde Pública-Fiocruz. Departamento de Ciências Biológicas. Laboratório de Toxicologia Ambiental. Rio de Janeiro. BR
  • Miranda, Elaine Silva; Escola Nacional de Saúde Pública-Fiocruz. Departamento de Ciências Biológicas. Laboratório de Toxicologia Ambiental. Rio de Janeiro. BR
  • Saint?Pierre, Tatiana Dillenburg; Escola Nacional de Saúde Pública-Fiocruz. Departamento de Ciências Biológicas. Laboratório de Toxicologia Ambiental. Rio de Janeiro. BR
  • Paumgartten, Francisco José Roma; Escola Nacional de Saúde Pública-Fiocruz. Departamento de Ciências Biológicas. Laboratório de Toxicologia Ambiental. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 109(4): 420-427, 03/07/2014. tab, graf
Article in English | LILACS | ID: lil-716312
Responsible library: BR1.1
ABSTRACT
Meglumine antimoniate (MA) and sodium stibogluconate are pentavalent antimony (SbV) drugs used since the mid-1940s. Notwithstanding the fact that they are first-choice drugs for the treatment of leishmaniases, there are gaps in our knowledge of their toxicological profile, mode of action and kinetics. Little is known about the distribution of antimony in tissues after SbV administration. In this study, we evaluated the Sb content of tissues from male rats 24 h and three weeks after a 21-day course of treatment with MA (300 mg SbV/kg body wt/d, subcutaneous). Sb concentrations in the blood and organs were determined by inductively coupled plasma-mass spectrometry. In rats, as with in humans, the Sb blood levels after MA dosing can be described by a two-compartment model with a fast (t1/2 = 0.6 h) and a slow (t1/2 >> 24 h) elimination phase. The spleen was the organ that accumulated the highest amount of Sb, while bone and thyroid ranked second in descending order of tissues according to Sb levels (spleen >> bone, thyroid, kidneys > liver, epididymis, lungs, adrenals > prostate > thymus, pancreas, heart, small intestines > skeletal muscle, testes, stomach > brain). The pathophysiological consequences of Sb accumulation in the thyroid and Sb speciation in the liver, thyroid, spleen and bone warrant further studies.
Subject(s)


Full text: Available Collection: International databases Database: LILACS Main subject: Organometallic Compounds / Meglumine / Antimony / Antiprotozoal Agents Type of study: Prognostic study Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2014 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Escola Nacional de Saúde Pública-Fiocruz/BR

Full text: Available Collection: International databases Database: LILACS Main subject: Organometallic Compounds / Meglumine / Antimony / Antiprotozoal Agents Type of study: Prognostic study Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2014 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Escola Nacional de Saúde Pública-Fiocruz/BR
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