Your browser doesn't support javascript.
loading
CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study
Santos, Erinaldo Ubirajara Damasceno dos; Lima, Géssica Dayane Cordeiro de; Oliveira, Micheline de Lucena; Heráclio, Sandra de Andrade; Silva, Hildson Dornelas Angelo da; Crovella, Sergio; Maia, Maria de Mascena Diniz; Souza/, Paulo Roberto Eleutério de.
Affiliation
  • Santos, Erinaldo Ubirajara Damasceno dos; Universidade Federal Rural de Pernambuco. Recife. BR
  • Lima, Géssica Dayane Cordeiro de; Universidade Federal Rural de Pernambuco. Recife. BR
  • Oliveira, Micheline de Lucena; Universidade Federal Rural de Pernambuco. Recife. BR
  • Heráclio, Sandra de Andrade; Universidade Federal Rural de Pernambuco. Recife. BR
  • Silva, Hildson Dornelas Angelo da; Universidade Federal Rural de Pernambuco. Recife. BR
  • Crovella, Sergio; Universidade Federal Rural de Pernambuco. Recife. BR
  • Maia, Maria de Mascena Diniz; Universidade Federal Rural de Pernambuco. Recife. BR
  • Souza/, Paulo Roberto Eleutério de; Universidade Federal Rural de Pernambuco. Recife. BR
Mem. Inst. Oswaldo Cruz ; 111(3): 174-180, Mar. 2016. tab
Article in English | LILACS | ID: lil-777375
Responsible library: BR1.1
ABSTRACT
Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.
Subject(s)


Full text: Available Collection: International databases Health context: Sustainable Health Agenda for the Americas / SDG3 - Health and Well-Being Health problem: Goal 9: Noncommunicable diseases and mental health / Target 3.3: End transmission of communicable diseases / Target 3.4: Reduce premature mortality due to noncommunicable diseases Database: LILACS Main subject: Polymorphism, Genetic / Uterine Cervical Diseases / Genetic Predisposition to Disease / Papillomavirus Infections Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Rural de Pernambuco/BR

Full text: Available Collection: International databases Health context: Sustainable Health Agenda for the Americas / SDG3 - Health and Well-Being Health problem: Goal 9: Noncommunicable diseases and mental health / Target 3.3: End transmission of communicable diseases / Target 3.4: Reduce premature mortality due to noncommunicable diseases Database: LILACS Main subject: Polymorphism, Genetic / Uterine Cervical Diseases / Genetic Predisposition to Disease / Papillomavirus Infections Type of study: Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Female / Humans Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Rural de Pernambuco/BR
...