Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease.

Sriram, Krishnan; Matheson, Joanna M; Benkovic, Stanley A; Miller, Diane B; Luster, Michael I; O'Callaghan, James P

Sriram, Krishnan; Matheson, Joanna M; Benkovic, Stanley A; Miller, Diane B; Luster, Michael I; O'Callaghan, James P.

Affiliation

Sriram K; Centers for Disease Control and Prevention-NIOSH, Morgantown, West Virginia 26505, USA.

FASEB J ; 16(11): 1474-6, 2002 Sep.

Article in En | MEDLINE | ID: mdl-12205053

Subject(s)

Dopamine Agents/toxicity; MPTP Poisoning/etiology; Receptors, Tumor Necrosis Factor/physiology; Tumor Necrosis Factor-alpha/physiology; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology; Animals; Corpus Striatum/drug effects; Corpus Striatum/metabolism; Cytoprotection; Dopamine/metabolism; Dopamine Agents/pharmacology; Glial Fibrillary Acidic Protein/biosynthesis; Glial Fibrillary Acidic Protein/genetics; Gliosis/chemically induced; Gliosis/etiology; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Parkinson Disease/etiology; RNA, Messenger/biosynthesis; Receptors, Tumor Necrosis Factor/genetics; Tumor Necrosis Factor-alpha/genetics; Tyrosine 3-Monooxygenase/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Dopamine Agents / Tumor Necrosis Factor-alpha / Receptors, Tumor Necrosis Factor / MPTP Poisoning Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2002 Document type: Article Affiliation country: United States Country of publication: United States

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