CD27low CD4 T lymphocytes that accumulate in the mouse lungs during mycobacterial infection differentiate from CD27high precursors in situ, produce IFN-gamma, and protect the host against tuberculosis infection.

Kapina, Marina A; Shepelkova, Galina S; Mischenko, Vladimir V; Sayles, Peter; Bogacheva, Polina; Winslow, Gary; Apt, Alexander S; Lyadova, Irina V

Kapina, Marina A; Shepelkova, Galina S; Mischenko, Vladimir V; Sayles, Peter; Bogacheva, Polina; Winslow, Gary; Apt, Alexander S; Lyadova, Irina V.

Affiliation

Kapina MA; Department of Immunology, Central Institute for Tuberculosis of the Russian Academy of Medical Sciences, Moscow, Russia.

J Immunol ; 178(2): 976-85, 2007 Jan 15.

Article in En | MEDLINE | ID: mdl-17202360

Subject(s)

CD4-Positive T-Lymphocytes/metabolism; Interferon-gamma/biosynthesis; Mycobacterium bovis/physiology; Mycobacterium tuberculosis/physiology; Tuberculosis/metabolism; Tuberculosis/prevention & control; Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism; Animals; Apoptosis; CD4-Positive T-Lymphocytes/cytology; Cell Movement; Down-Regulation; Female; Lymphoid Tissue/cytology; Lymphoid Tissue/metabolism; Mice; Mice, Inbred C57BL; Tuberculosis/microbiology

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / CD4-Positive T-Lymphocytes / Interferon-gamma / Tumor Necrosis Factor Receptor Superfamily, Member 7 / Mycobacterium bovis / Mycobacterium tuberculosis Limits: Animals Language: En Journal: J Immunol Year: 2007 Document type: Article Affiliation country: RUSSIA Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links