Mechanism-based pharmacokinetic-pharmacodynamic modeling of the estrogen-like effect of ginsenoside Rb1 on neural 5-HT in ovariectomized mice.

Hao, Kun; Gong, Ping; Sun, Shi-Qing; Hao, Hai-Ping; Wang, Guang-Ji; Dai, Yue; Chen, Yuan-Cheng; Liang, Yan; Xie, Lin; Li, Fei-Yan; Li, Hao-Ye

Hao, Kun; Gong, Ping; Sun, Shi-Qing; Hao, Hai-Ping; Wang, Guang-Ji; Dai, Yue; Chen, Yuan-Cheng; Liang, Yan; Xie, Lin; Li, Fei-Yan; Li, Hao-Ye.

Affiliation

Hao K; Key Lab of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University, Nanjing, PR China.

Eur J Pharm Sci ; 44(1-2): 117-26, 2011 Sep 18.

Article in En | MEDLINE | ID: mdl-21740969

Subject(s)

Brain/drug effects; Ginsenosides; Models, Biological; Neurons/drug effects; Phytoestrogens; Serotonin/metabolism; 5-Hydroxytryptophan/metabolism; Animals; Brain/enzymology; Brain/metabolism; Dose-Response Relationship, Drug; Estradiol/blood; Estradiol/pharmacokinetics; Estradiol/pharmacology; Female; Ginsenosides/pharmacokinetics; Ginsenosides/pharmacology; Indoles/metabolism; Mice; Mice, Inbred Strains; Neurons/enzymology; Neurons/metabolism; Ovariectomy; Phytoestrogens/pharmacokinetics; Phytoestrogens/pharmacology; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Serotonin / Ginsenosides / Phytoestrogens / Models, Biological / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2011 Document type: Article Country of publication: Netherlands

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