Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy.

De Moor, Olivier; Dorgan, Colin R; Johnson, Peter D; Lambert, Adam G; Lecci, Cristina; Maillol, Carole; Nugent, Gary; Poignant, Séverine D; Price, Paul D; Pye, Richard J; Storer, Richard; Tinsley, Jonathon M; Vickers, Richard; Well, Renate van; Wilkes, Fraser J; Wilson, Francis X; Wren, Stephen P; Wynne, Graham M

De Moor, Olivier; Dorgan, Colin R; Johnson, Peter D; Lambert, Adam G; Lecci, Cristina; Maillol, Carole; Nugent, Gary; Poignant, Séverine D; Price, Paul D; Pye, Richard J; Storer, Richard; Tinsley, Jonathon M; Vickers, Richard; Well, Renate van; Wilkes, Fraser J; Wilson, Francis X; Wren, Stephen P; Wynne, Graham M.

Affiliation

De Moor O; Summit plc., 91 Milton Park, Abingdon, Oxfordshire OX14 4RY, United Kingdom.

Bioorg Med Chem Lett ; 21(16): 4828-31, 2011 Aug 15.

Article in En | MEDLINE | ID: mdl-21741236

Subject(s)

Drug Discovery; Indazoles/chemical synthesis; Microsomes, Liver/drug effects; Triazoles/chemical synthesis; Dose-Response Relationship, Drug; Humans; Indazoles/chemistry; Indazoles/therapeutic use; Molecular Structure; Muscular Dystrophy, Duchenne/drug therapy; Solubility; Stereoisomerism; Structure-Activity Relationship; Triazoles/chemistry; Triazoles/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Microsomes, Liver / Drug Discovery / Indazoles Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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