Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis.

Ohashi, Kazumasa; Sato, Atsuyasu; Takada, Toshinori; Arai, Toru; Nei, Takahito; Kasahara, Yasunori; Motoi, Natsuki; Hojo, Masayuki; Urano, Shinya; Ishii, Haruyuki; Yokoba, Masanori; Eda, Ryosuke; Nakayama, Hideaki; Nasuhara, Yasuyuki; Tsuchihashi, Yoshiko; Kaneko, Chinatsu; Kanazawa, Hiroko; Ebina, Masahito; Yamaguchi, Etsuro; Kirchner, Jacqueline; Inoue, Yoshikazu; Nakata, Koh; Tazawa, Ryushi

Ohashi, Kazumasa; Sato, Atsuyasu; Takada, Toshinori; Arai, Toru; Nei, Takahito; Kasahara, Yasunori; Motoi, Natsuki; Hojo, Masayuki; Urano, Shinya; Ishii, Haruyuki; Yokoba, Masanori; Eda, Ryosuke; Nakayama, Hideaki; Nasuhara, Yasuyuki; Tsuchihashi, Yoshiko; Kaneko, Chinatsu; Kanazawa, Hiroko; Ebina, Masahito; Yamaguchi, Etsuro; Kirchner, Jacqueline; Inoue, Yoshikazu; Nakata, Koh; Tazawa, Ryushi.

Affiliation

Ohashi K; Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1-754 Asahimachi-dori, Niigata 951-8520, Japan.

Respir Med ; 106(2): 284-93, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22112784

Subject(s)

Bronchoalveolar Lavage Fluid; Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use; Lung/metabolism; Pulmonary Alveolar Proteinosis/metabolism; Pulmonary Surfactant-Associated Protein A/metabolism; Pulmonary Surfactants/metabolism; Respiratory Therapy; Administration, Inhalation; Autoantibodies/immunology; Bronchoalveolar Lavage Fluid/immunology; Evidence-Based Medicine; Female; Granulocyte-Macrophage Colony-Stimulating Factor/immunology; Humans; Immunohistochemistry; Interleukin-17/immunology; Lung/immunology; Lung/pathology; Macrophages, Alveolar/drug effects; Male; Middle Aged; Pilot Projects; Pulmonary Alveolar Proteinosis/drug therapy; Pulmonary Alveolar Proteinosis/immunology; Pulmonary Alveolar Proteinosis/pathology; Pulmonary Surfactant-Associated Protein A/immunology; Pulmonary Surfactants/immunology; Respiratory Therapy/methods; Retrospective Studies; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Alveolar Proteinosis / Respiratory Therapy / Pulmonary Surfactants / Bronchoalveolar Lavage Fluid / Granulocyte-Macrophage Colony-Stimulating Factor / Pulmonary Surfactant-Associated Protein A / Lung Type of study: Guideline / Observational_studies / Risk_factors_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Respir Med Year: 2012 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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