Multiple antigenic peptides based on H-2K(b)-restricted CTL epitopes from murine heparanase induce a potent antitumor immune response in vivo.

Tang, Xu-Dong; Wang, Guo-Zhen; Guo, Jun; Lü, Mu-Han; Li, Chuan; Li, Ning; Chao, Ya-Ling; Li, Chang-Zhu; Wu, Yu-Yun; Hu, Chang-Jiang; Fang, Dian-Chun; Yang, Shi-Ming

Tang, Xu-Dong; Wang, Guo-Zhen; Guo, Jun; Lü, Mu-Han; Li, Chuan; Li, Ning; Chao, Ya-Ling; Li, Chang-Zhu; Wu, Yu-Yun; Hu, Chang-Jiang; Fang, Dian-Chun; Yang, Shi-Ming.

Affiliation

Tang XD; Institute of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, PR China.

Mol Cancer Ther ; 11(5): 1183-92, 2012 May.

Article in En | MEDLINE | ID: mdl-22442309

Subject(s)

Epitopes, T-Lymphocyte/immunology; Glucuronidase/immunology; H-2 Antigens/immunology; Neoplasms/immunology; Peptides/immunology; T-Lymphocytes, Cytotoxic/immunology; Amino Acid Sequence; Animals; Cancer Vaccines/immunology; Cell Line, Tumor; Cytotoxicity, Immunologic/immunology; Dendritic Cells/immunology; Dendritic Cells/metabolism; Epitopes, T-Lymphocyte/chemistry; Epitopes, T-Lymphocyte/isolation & purification; Glucuronidase/chemistry; Glucuronidase/isolation & purification; Humans; Immunophenotyping; Immunotherapy; Interferon-gamma/biosynthesis; Mice; Mice, Inbred C57BL; Neoplasms/mortality; Neoplasms/therapy; Peptides/chemistry; Peptides/isolation & purification

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / T-Lymphocytes, Cytotoxic / H-2 Antigens / Epitopes, T-Lymphocyte / Glucuronidase / Neoplasms Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2012 Document type: Article Country of publication: United States

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