Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus.

Hofer, Markus J; Li, Wen; Manders, Peter; Terry, Rachael; Lim, Sue Ling; King, Nicholas J C; Campbell, Iain L

Hofer, Markus J; Li, Wen; Manders, Peter; Terry, Rachael; Lim, Sue Ling; King, Nicholas J C; Campbell, Iain L.

Affiliation

Hofer MJ; School of Molecular Bioscience and the Bosch Institute, University of Sydney, Sydney, NSW, Australia.

J Virol ; 86(12): 6932-46, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22496215

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Interferon-Stimulated Gene Factor 3, gamma Subunit/immunology; Lymphocytic Choriomeningitis/immunology; Lymphocytic choriomeningitis virus/physiology; STAT1 Transcription Factor/immunology; STAT2 Transcription Factor/immunology; Animals; CD4-Positive T-Lymphocytes/virology; Female; Humans; Interferon-Stimulated Gene Factor 3, gamma Subunit/deficiency; Interferon-Stimulated Gene Factor 3, gamma Subunit/genetics; Interferons/genetics; Interferons/immunology; Lymphocytic Choriomeningitis/genetics; Lymphocytic Choriomeningitis/virology; Lymphocytic choriomeningitis virus/genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; STAT1 Transcription Factor/deficiency; STAT1 Transcription Factor/genetics; STAT2 Transcription Factor/deficiency; STAT2 Transcription Factor/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / STAT1 Transcription Factor / STAT2 Transcription Factor / Interferon-Stimulated Gene Factor 3, gamma Subunit / Lymphocytic Choriomeningitis / Lymphocytic choriomeningitis virus Limits: Animals / Female / Humans / Male Language: En Journal: J Virol Year: 2012 Document type: Article Affiliation country: Australia Country of publication: United States

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