Utility of standard pharmacopeial and nonpharmacopeial methods in distinguishing folded, unfolded, and process variant forms of interferon &#945;-2.

Mark, John K; Dionne, Sophie; Cyr, Terry D; Boucher, Sylvie; Girard, Michel; Hefford, Mary Alice

Utility of standard pharmacopeial and nonpharmacopeial methods in distinguishing folded, unfolded, and process variant forms of interferon α-2.

Mark, John K; Dionne, Sophie; Cyr, Terry D; Boucher, Sylvie; Girard, Michel; Hefford, Mary Alice.

Affiliation

Mark JK; Biologics and Genetic Therapies Directorate, Health Canada-Santé Canada, Ottawa, Ontario K1A 0K9, Canada.

J Pharm Sci ; 101(10): 3672-86, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22828964

Subject(s)

Interferon-alpha/chemistry; Circular Dichroism/methods; Electrophoresis, Capillary/methods; HEK293 Cells; Humans; Interferon-alpha/analysis; Mass Spectrometry/methods; Protein Conformation; Protein Folding; Spectrometry, Fluorescence/methods; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-alpha Type of study: Guideline Limits: Humans Language: En Journal: J Pharm Sci Year: 2012 Document type: Article Affiliation country: Canada Country of publication: United States

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