The proline-rich tyrosine kinase Pyk2 regulates platelet integrin &#945;IIbß3 outside-in signaling.

Cipolla, L; Consonni, A; Guidetti, G; Canobbio, I; Okigaki, M; Falasca, M; Ciraolo, E; Hirsch, E; Balduini, C; Torti, M

The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbß3 outside-in signaling.

Cipolla, L; Consonni, A; Guidetti, G; Canobbio, I; Okigaki, M; Falasca, M; Ciraolo, E; Hirsch, E; Balduini, C; Torti, M.

Affiliation

Cipolla L; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy.

J Thromb Haemost ; 11(2): 345-56, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23216754

Subject(s)

Blood Platelets/enzymology; Focal Adhesion Kinase 2/metabolism; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism; Signal Transduction; Animals; Cell Shape; Enzyme Activation; Fibrinogen/metabolism; Focal Adhesion Kinase 1/metabolism; Focal Adhesion Kinase 2/deficiency; Focal Adhesion Kinase 2/genetics; Humans; Integrin alpha2/metabolism; Integrin beta3/metabolism; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinase/genetics; Phosphatidylinositol 3-Kinase/metabolism; Phospholipase C gamma/genetics; Phospholipase C gamma/metabolism; Phosphorylation; Platelet Adhesiveness; Proto-Oncogene Proteins c-abl/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Time Factors; rap GTP-Binding Proteins/metabolism; src-Family Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Signal Transduction / Platelet Glycoprotein GPIIb-IIIa Complex / Focal Adhesion Kinase 2 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Thromb Haemost Journal subject: HEMATOLOGIA Year: 2013 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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