Human parainfluenza virus type 2 V protein inhibits TRAF6-mediated ubiquitination of IRF7 to prevent TLR7- and TLR9-dependent interferon induction.

Kitagawa, Yoshinori; Yamaguchi, Mayu; Zhou, Min; Nishio, Machiko; Itoh, Masae; Gotoh, Bin

Kitagawa, Yoshinori; Yamaguchi, Mayu; Zhou, Min; Nishio, Machiko; Itoh, Masae; Gotoh, Bin.

Affiliation

Kitagawa Y; Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.

J Virol ; 87(14): 7966-76, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23678181

Subject(s)

Interferon Regulatory Factor-7/metabolism; Interferon-alpha/metabolism; Parainfluenza Virus 2, Human/metabolism; Signal Transduction/physiology; TNF Receptor-Associated Factor 6/metabolism; Viral Proteins/metabolism; Gene Knockdown Techniques; HEK293 Cells; Humans; I-kappa B Kinase/metabolism; Immunoprecipitation; Myeloid Differentiation Factor 88/metabolism; TNF Receptor-Associated Factor 6/genetics; Toll-Like Receptor 7/metabolism; Toll-Like Receptor 9/metabolism; Ubiquitination/drug effects; Viral Proteins/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Signal Transduction / Interferon-alpha / Parainfluenza Virus 2, Human / TNF Receptor-Associated Factor 6 / Interferon Regulatory Factor-7 Limits: Humans Language: En Journal: J Virol Year: 2013 Document type: Article Affiliation country: Japan Country of publication: United States

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