Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia.

Roderick, Justine E; Gonzalez-Perez, Gabriela; Kuksin, Christina Arieta; Dongre, Anushka; Roberts, Emily R; Srinivasan, Janani; Andrzejewski, Chester; Fauq, Abdul H; Golde, Todd E; Miele, Lucio; Minter, Lisa M

Roderick, Justine E; Gonzalez-Perez, Gabriela; Kuksin, Christina Arieta; Dongre, Anushka; Roberts, Emily R; Srinivasan, Janani; Andrzejewski, Chester; Fauq, Abdul H; Golde, Todd E; Miele, Lucio; Minter, Lisa M.

Affiliation

Roderick JE; Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, MA 01003, USA.

J Exp Med ; 210(7): 1311-29, 2013 Jul 01.

Article in En | MEDLINE | ID: mdl-23733784

Subject(s)

Anemia, Aplastic/immunology; Anemia, Aplastic/therapy; Bone Marrow/immunology; Bone Marrow/pathology; Receptor, Notch1/physiology; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Anemia, Aplastic/pathology; Animals; Disease Models, Animal; Enzyme Inhibitors/therapeutic use; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Receptor, Notch1/deficiency; Receptor, Notch1/genetics; Signal Transduction/drug effects; Signal Transduction/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Receptor, Notch1 / Anemia, Aplastic Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Exp Med Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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