Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.

Lee, Hyun; Cao, Shuyi; Hevener, Kirk E; Truong, Lena; Gatuz, Joseph L; Patel, Kavankumar; Ghosh, Arun K; Johnson, Michael E

Lee, Hyun; Cao, Shuyi; Hevener, Kirk E; Truong, Lena; Gatuz, Joseph L; Patel, Kavankumar; Ghosh, Arun K; Johnson, Michael E.

Affiliation

Lee H; Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry & Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60607, USA.

ChemMedChem ; 8(8): 1361-72, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23788528

Subject(s)

Antiviral Agents/chemistry; Drug Design; Protease Inhibitors/chemistry; Severe acute respiratory syndrome-related coronavirus/enzymology; Viral Proteins/antagonists & inhibitors; Antiviral Agents/metabolism; Binding Sites; Coronavirus 3C Proteases; Cysteine Endopeptidases/metabolism; Drug Synergism; Humans; Kinetics; Molecular Docking Simulation; Protease Inhibitors/metabolism; Protein Binding; Protein Structure, Tertiary; Small Molecule Libraries/chemistry; Small Molecule Libraries/metabolism; Surface Plasmon Resonance; Viral Proteins/metabolism

Key words

fragments; human SARS coronavirus; inhibitors; papain-like protease; small molecules

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Viral Proteins / Drug Design / Severe acute respiratory syndrome-related coronavirus Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2013 Document type: Article Affiliation country: United States Country of publication: Germany

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