Repression of inflammasome by Francisella tularensis during early stages of infection.

Dotson, Rachel J; Rabadi, Seham M; Westcott, Elizabeth L; Bradley, Stephen; Catlett, Sally V; Banik, Sukalyani; Harton, Jonathan A; Bakshi, Chandra Shekhar; Malik, Meenakshi

Dotson, Rachel J; Rabadi, Seham M; Westcott, Elizabeth L; Bradley, Stephen; Catlett, Sally V; Banik, Sukalyani; Harton, Jonathan A; Bakshi, Chandra Shekhar; Malik, Meenakshi.

Affiliation

Dotson RJ; Albany College of Pharmacy and Health Sciences, Albany, New York 12208, USA.

J Biol Chem ; 288(33): 23844-57, 2013 Aug 16.

Article in En | MEDLINE | ID: mdl-23821549

Subject(s)

Francisella tularensis/immunology; Inflammasomes/metabolism; Tularemia/immunology; Tularemia/microbiology; Animals; Carrier Proteins/metabolism; Cell Death; DNA-Binding Proteins; Humans; Interferon-beta/metabolism; Interleukin-18/metabolism; Interleukin-1beta/metabolism; Macrophages/metabolism; Macrophages/microbiology; Macrophages/pathology; Mice; Mice, Inbred C57BL; Mutation/genetics; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Proteins/metabolism; Signal Transduction/immunology; Toll-Like Receptor 2/metabolism; Toll-Like Receptor 4/metabolism

Key words

Bacterial Pathogenesis; Cytokine; Francisella; Il-1b; Immune Subversion; Immunosuppression; Inflammasome; Inflammation; Macrophages

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tularemia / Inflammasomes / Francisella tularensis Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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