Blocking porcine sialoadhesin improves extracorporeal porcine liver xenoperfusion with human blood.

Waldman, Joshua P; Vogel, Thomas; Burlak, Christopher; Coussios, Constantin; Dominguez, Javier; Friend, Peter; Rees, Michael A

Waldman, Joshua P; Vogel, Thomas; Burlak, Christopher; Coussios, Constantin; Dominguez, Javier; Friend, Peter; Rees, Michael A.

Affiliation

Waldman JP; Department of Urology, University of Toledo Medical Center, Toledo, OH 43614, USA.

Xenotransplantation ; 20(4): 239-51, 2013.

Article in En | MEDLINE | ID: mdl-23822217

Subject(s)

Erythrocyte Transfusion/methods; Extracorporeal Circulation/methods; Liver/blood supply; Perfusion/methods; Sialic Acid Binding Ig-like Lectin 1/antagonists & inhibitors; Transplantation, Heterologous/methods; Animals; Antibodies, Anti-Idiotypic/immunology; Antibodies, Anti-Idiotypic/pharmacology; Erythrocytes/drug effects; Humans; In Vitro Techniques; Kupffer Cells/physiology; Models, Animal; Phagocytosis/physiology; Sialic Acid Binding Ig-like Lectin 1/drug effects; Sialic Acid Binding Ig-like Lectin 1/immunology; Swine; Time Factors

Key words

acute liver failure; adhesion molecules; hepatic failure; kupffer cells; liver assist/support; liver failure; liver support devices; macrophages; xenograft rejection; xenoperfusion; xenotransplantation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Perfusion / Transplantation, Heterologous / Erythrocyte Transfusion / Extracorporeal Circulation / Sialic Acid Binding Ig-like Lectin 1 / Liver Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Xenotransplantation Journal subject: TRANSPLANTE Year: 2013 Document type: Article Affiliation country: United States Country of publication: Denmark

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