Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.

Butchi, Niranjan B; Hinton, David R; Stohlman, Stephen A; Kapil, Parul; Fensterl, Volker; Sen, Ganes C; Bergmann, Cornelia C

Butchi, Niranjan B; Hinton, David R; Stohlman, Stephen A; Kapil, Parul; Fensterl, Volker; Sen, Ganes C; Bergmann, Cornelia C.

Affiliation

Butchi NB; Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

J Virol ; 88(2): 1051-64, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24198415

Subject(s)

Central Nervous System/virology; Encephalitis/veterinary; Interferon-alpha/genetics; Interferon-beta/genetics; Macrophages/immunology; Murine hepatitis virus/physiology; Proteins/immunology; Rodent Diseases/immunology; Animals; Apoptosis Regulatory Proteins; Central Nervous System/immunology; Encephalitis/genetics; Encephalitis/immunology; Encephalitis/virology; Female; Interferon-alpha/immunology; Interferon-beta/immunology; Macrophages/virology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Murine hepatitis virus/genetics; Proteins/genetics; RNA-Binding Proteins; Rodent Diseases/genetics; Rodent Diseases/virology; Viral Tropism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rodent Diseases / Proteins / Central Nervous System / Interferon-beta / Interferon-alpha / Murine hepatitis virus / Encephalitis / Macrophages Limits: Animals Language: En Journal: J Virol Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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