17ß-estradiol upregulates GREB1 and accelerates ovarian tumor progression in vivo.

Laviolette, Laura A; Hodgkinson, Kendra M; Minhas, Neha; Perez-Iratxeta, Carol; Vanderhyden, Barbara C

Laviolette, Laura A; Hodgkinson, Kendra M; Minhas, Neha; Perez-Iratxeta, Carol; Vanderhyden, Barbara C.

Affiliation

Laviolette LA; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Int J Cancer ; 135(5): 1072-84, 2014 Sep 01.

Article in En | MEDLINE | ID: mdl-24469735

Subject(s)

Estradiol/pharmacology; Neoplasm Proteins/biosynthesis; Neoplasms, Glandular and Epithelial/pathology; Ovarian Neoplasms/pathology; Tumor Burden/drug effects; Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Disease Progression; Down-Regulation; Female; Gene Expression Regulation, Neoplastic/drug effects; Humans; Mice; Mice, SCID; Neoplasm Proteins/genetics; Neoplasms, Glandular and Epithelial/genetics; Ovarian Neoplasms/genetics; RNA Interference; RNA, Small Interfering/genetics; Up-Regulation

Key words

GREB1; estrogen; microarray; mouse model; ovarian cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Neoplasms, Glandular and Epithelial / Tumor Burden / Estradiol / Neoplasm Proteins Type of study: Clinical_trials Limits: Animals / Female / Humans Language: En Journal: Int J Cancer Year: 2014 Document type: Article Affiliation country: Canada Country of publication: United States

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