CD8(+) T cells mediate robust stage-specific immunity to P. berghei under chemoprophylaxis and this protective environment is not downregulated by the presence of blood-stage infection.

Lewis, Matthew D; Pfeil, Johannes; Heiss, Kirsten; Mueller, Ann-Kristin

Lewis, Matthew D; Pfeil, Johannes; Heiss, Kirsten; Mueller, Ann-Kristin.

Affiliation

Lewis MD; Department of Infectious Diseases, Parasitology Unit, University Hospital Heidelberg, Heidelberg, Germany.
Pfeil J; Department of Infectious Diseases, Parasitology Unit, University Hospital Heidelberg, Heidelberg, Germany ; Centre for Childhood and Adolescence Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Heiss K; Department of Infectious Diseases, Parasitology Unit, University Hospital Heidelberg, Heidelberg, Germany.
Mueller AK; Department of Infectious Diseases, Parasitology Unit, University Hospital Heidelberg, Heidelberg, Germany.

PLoS One ; 9(2): e88117, 2014.

Article in En | MEDLINE | ID: mdl-24516592

Subject(s)

Antimalarials/therapeutic use; CD8-Positive T-Lymphocytes/immunology; Chloroquine/therapeutic use; Malaria Vaccines/therapeutic use; Malaria/prevention & control; Plasmodium berghei; Animals; Antimalarials/pharmacology; CD8-Positive T-Lymphocytes/drug effects; Chemoprevention; Chloroquine/pharmacology; Combined Modality Therapy; Immunization; Immunologic Memory/drug effects; Immunologic Memory/immunology; Malaria/immunology; Mice; Sporozoites/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium berghei / Chloroquine / Malaria Vaccines / CD8-Positive T-Lymphocytes / Malaria / Antimalarials Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: Germany Country of publication: United States

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