The glycosylated Rv1860 protein of Mycobacterium tuberculosis inhibits dendritic cell mediated TH1 and TH17 polarization of T cells and abrogates protective immunity conferred by BCG.

Satchidanandam, Vijaya; Kumar, Naveen; Jumani, Rajiv S; Challu, Vijay; Elangovan, Shobha; Khan, Naseem A

Satchidanandam, Vijaya; Kumar, Naveen; Jumani, Rajiv S; Challu, Vijay; Elangovan, Shobha; Khan, Naseem A.

Affiliation

Satchidanandam V; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India.
Kumar N; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India.
Jumani RS; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India.
Challu V; National Tuberculosis Institute, Bangalore, Karnataka, India.
Elangovan S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India.
Khan NA; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India.

PLoS Pathog ; 10(6): e1004176, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24945624

Subject(s)

Adaptive Immunity; BCG Vaccine/adverse effects; Bacterial Proteins/adverse effects; Dendritic Cells/immunology; Glycoproteins/adverse effects; Immunologic Memory; Mycobacterium tuberculosis/immunology; Animals; BCG Vaccine/antagonists & inhibitors; BCG Vaccine/therapeutic use; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bacterial Proteins/therapeutic use; Cell Polarity; Cells, Cultured; Dendritic Cells/metabolism; Dendritic Cells/microbiology; Female; Glycoproteins/genetics; Glycoproteins/metabolism; Glycoproteins/therapeutic use; Glycosylation; Inflammation Mediators/metabolism; Macrophages, Peritoneal/immunology; Macrophages, Peritoneal/metabolism; Macrophages, Peritoneal/microbiology; Mice, Inbred BALB C; Mycobacterium bovis/immunology; Mycobacterium bovis/metabolism; Mycobacterium tuberculosis/metabolism; Protein Processing, Post-Translational; Recombinant Proteins/adverse effects; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Recombinant Proteins/therapeutic use; Spleen/immunology; Spleen/metabolism; Spleen/microbiology; Th1 Cells/immunology; Th1 Cells/metabolism; Th1 Cells/microbiology; Th17 Cells/immunology; Th17 Cells/metabolism; Th17 Cells/microbiology; Tuberculosis/immunology; Tuberculosis/metabolism; Tuberculosis/microbiology; Tuberculosis/prevention & control

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Dendritic Cells / BCG Vaccine / Glycoproteins / Adaptive Immunity / Immunologic Memory / Mycobacterium tuberculosis Language: En Journal: PLoS Pathog Year: 2014 Document type: Article Affiliation country: India Country of publication: United States

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