Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.

Agyeman, Akwasi; Jha, Babal K; Mazumdar, Tapati; Houghton, Janet A

Agyeman, Akwasi; Jha, Babal K; Mazumdar, Tapati; Houghton, Janet A.

Affiliation

Agyeman A; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Houghton JA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

Oncotarget ; 5(12): 4492-503, 2014 Jun 30.

Article in En | MEDLINE | ID: mdl-24962990

Subject(s)

Colonic Neoplasms/metabolism; Hedgehog Proteins/metabolism; Pyridines/metabolism; Pyrimidines/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism; Cell Line, Tumor; Cell Survival; Humans; Kruppel-Like Factor 4; Signal Transduction; Transfection; Zinc Finger Protein GLI1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / Transcription Factors / Colonic Neoplasms / Hedgehog Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Oncotarget Year: 2014 Document type: Article Country of publication: United States

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