The dengue virus NS5 protein as a target for drug discovery.

Lim, Siew Pheng; Noble, Christian G; Shi, Pei-Yong

Lim, Siew Pheng; Noble, Christian G; Shi, Pei-Yong.

Affiliation

Lim SP; Novartis Institute for Tropical Diseases, 10 Biopolis Road, 05-01 Chromos, Singapore 138670, Singapore. Electronic address: siew_pheng.lim@novartis.com.
Noble CG; Novartis Institute for Tropical Diseases, 10 Biopolis Road, 05-01 Chromos, Singapore 138670, Singapore. Electronic address: christian.noble@novartis.com.
Shi PY; Novartis Institute for Tropical Diseases, 10 Biopolis Road, 05-01 Chromos, Singapore 138670, Singapore.

Antiviral Res ; 119: 57-67, 2015 Jul.

Article in En | MEDLINE | ID: mdl-25912817

Subject(s)

Dengue Virus/chemistry; Drug Discovery; RNA-Dependent RNA Polymerase; Viral Nonstructural Proteins; Antiviral Agents/pharmacology; Dengue Virus/drug effects; Dengue Virus/genetics; Enzyme Inhibitors/pharmacology; Methyltransferases/antagonists & inhibitors; Methyltransferases/chemistry; Methyltransferases/metabolism; Prospective Studies; Protein Structure, Tertiary; RNA, Viral/metabolism; RNA-Dependent RNA Polymerase/antagonists & inhibitors; RNA-Dependent RNA Polymerase/chemistry; RNA-Dependent RNA Polymerase/metabolism; Severe Dengue/drug therapy; Viral Nonstructural Proteins/antagonists & inhibitors; Viral Nonstructural Proteins/chemistry; Viral Nonstructural Proteins/metabolism; Virus Replication

Key words

Antiviral; Dengue hemorrhagic fever; Dengue virus; Methyltransferase; NS5 protein; RNA polymerase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA-Dependent RNA Polymerase / Viral Nonstructural Proteins / Dengue Virus / Drug Discovery Type of study: Observational_studies Language: En Journal: Antiviral Res Year: 2015 Document type: Article Country of publication: Netherlands

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