Leishmania donovani P23 protects parasites against HSP90 inhibitor-mediated growth arrest.

Hombach, Antje; Ommen, Gabi; Sattler, Victoria; Clos, Joachim

Hombach, Antje; Ommen, Gabi; Sattler, Victoria; Clos, Joachim.

Affiliation

Hombach A; Bernhard Nocht Institute for Tropical Medicine, P.O. Box 30 41 20, 20324, Hamburg, Germany.

Cell Stress Chaperones ; 20(4): 673-85, 2015 Jul.

Article in En | MEDLINE | ID: mdl-25948161

Subject(s)

HSP90 Heat-Shock Proteins/antagonists & inhibitors; Leishmania donovani/metabolism; Molecular Chaperones/metabolism; Protozoan Proteins/metabolism; Animals; Benzoquinones/pharmacology; Female; HSP90 Heat-Shock Proteins/metabolism; Lactams, Macrocyclic/pharmacology; Leishmania donovani/growth & development; Leishmania donovani/pathogenicity; Life Cycle Stages/drug effects; Macrolides/pharmacology; Macrophages/cytology; Macrophages/metabolism; Macrophages/parasitology; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Molecular Chaperones/genetics; Protozoan Proteins/genetics; Real-Time Polymerase Chain Reaction; Recombinant Proteins/biosynthesis; Recombinant Proteins/chemistry; Recombinant Proteins/isolation & purification; Transcriptome; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leishmania donovani / Protozoan Proteins / Molecular Chaperones / HSP90 Heat-Shock Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Stress Chaperones Year: 2015 Document type: Article Affiliation country: Germany Country of publication: Netherlands

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