Isolation, characterization, and anthelminthic activities of a novel dichapetalin and other constituents of Dichapetalum filicaule.

Chama, Mary Anti; Dziwornu, Godwin Akpeko; Waibel, Reiner; Osei-Safo, Dorcas; Addae-Mensah, Ivan; Otchere, Joseph; Wilson, Michael

Chama, Mary Anti; Dziwornu, Godwin Akpeko; Waibel, Reiner; Osei-Safo, Dorcas; Addae-Mensah, Ivan; Otchere, Joseph; Wilson, Michael.

Affiliation

Chama MA; a Department of Chemistry , University of Ghana , Legon , Ghana .
Dziwornu GA; a Department of Chemistry , University of Ghana , Legon , Ghana .
Waibel R; b Department of Chemistry and Pharmacy , Friederich Alexander University of Erlangen-Nurnberg , Erlangen , Germany , and.
Osei-Safo D; a Department of Chemistry , University of Ghana , Legon , Ghana .
Addae-Mensah I; a Department of Chemistry , University of Ghana , Legon , Ghana .
Otchere J; c Department of Parasitology , Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana , Legon , Ghana.
Wilson M; c Department of Parasitology , Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana , Legon , Ghana.

Pharm Biol ; 54(7): 1179-88, 2016 Jul.

Article in En | MEDLINE | ID: mdl-26118692

Subject(s)

Anthelmintics/pharmacology; Heterocyclic Compounds, 4 or More Rings/pharmacology; Magnoliopsida; Necator americanus/drug effects; Plant Extracts/pharmacology; Spiro Compounds/pharmacology; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anthelmintics/isolation & purification; Child; Child, Preschool; Chromatography, Thin Layer; Female; Heterocyclic Compounds, 4 or More Rings/isolation & purification; Humans; Magnetic Resonance Spectroscopy; Magnoliopsida/chemistry; Male; Mass Spectrometry; Middle Aged; Necator americanus/genetics; Necator americanus/growth & development; Parasite Egg Count; Parasitic Sensitivity Tests; Phytotherapy; Plant Extracts/isolation & purification; Plant Roots; Plants, Medicinal; Solvents/chemistry; Spiro Compounds/isolation & purification; Young Adult

Key words

Dichapetalaceae; Necator americanus; dichapetalin X; glycerol monostearate; hookworm; pomolic acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spiro Compounds / Plant Extracts / Necator americanus / Magnoliopsida / Heterocyclic Compounds, 4 or More Rings / Anthelmintics Limits: Adolescent / Adult / Aged / Aged80 / Animals / Child / Child, preschool / Female / Humans / Male Language: En Journal: Pharm Biol Year: 2016 Document type: Article Affiliation country: Ghana Country of publication: United kingdom

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