Determination and Therapeutic Exploitation of Ebola Virus Spontaneous Mutation Frequency.

Alfson, Kendra J; Worwa, Gabriella; Carrion, Ricardo; Griffiths, Anthony

Alfson, Kendra J; Worwa, Gabriella; Carrion, Ricardo; Griffiths, Anthony.

Affiliation

Alfson KJ; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Worwa G; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Carrion R; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Griffiths A; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, USA agriffiths@txbiomed.org.

J Virol ; 90(5): 2345-55, 2015 Dec 16.

Article in En | MEDLINE | ID: mdl-26676781

Subject(s)

Ebolavirus/genetics; Genetic Variation; Mutation Rate; Animals; Antiviral Agents/administration & dosage; Antiviral Agents/pharmacology; Disease Models, Animal; Female; Genes, Reporter; Green Fluorescent Proteins/genetics; Hemorrhagic Fever, Ebola/drug therapy; High-Throughput Nucleotide Sequencing; Humans; Inhibitory Concentration 50; Macaca fascicularis; Male; Mice, Inbred BALB C; Microbial Sensitivity Tests; RNA, Viral/genetics; Ribavirin/administration & dosage; Ribavirin/pharmacology; Sequence Analysis, DNA; Survival Analysis; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Ebolavirus / Mutation Rate Limits: Animals / Female / Humans / Male Language: En Journal: J Virol Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States

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