Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis.

Valentin-Torres, Alice; Savarin, Carine; Hinton, David R; Phares, Timothy W; Bergmann, Cornelia C; Stohlman, Stephen A

Valentin-Torres, Alice; Savarin, Carine; Hinton, David R; Phares, Timothy W; Bergmann, Cornelia C; Stohlman, Stephen A.

Affiliation

Valentin-Torres A; Department of Neurosciences NC-30, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA. valenta@ccf.org.
Savarin C; Department of Neurosciences NC-30, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA. savaric@ccf.org.
Hinton DR; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. dhinton@usc.edu.
Phares TW; Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA. timothy.w.phares.ctr@mail.mil.
Bergmann CC; Department of Neurosciences NC-30, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA. bergmac@ccf.org.
Stohlman SA; Department of Neurosciences NC-30, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA. stohlms2@ccf.org.

J Neuroinflammation ; 13: 46, 2016 Feb 22.

Article in En | MEDLINE | ID: mdl-26906225

Subject(s)

Central Nervous System/pathology; Encephalomyelitis, Autoimmune, Experimental/pathology; Macrophages/metabolism; Tumor Necrosis Factor-alpha/metabolism; Animals; Antibodies/pharmacology; Antigens, CD/metabolism; Blood-Brain Barrier/physiopathology; Calcium-Binding Proteins/metabolism; Capillary Permeability/genetics; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental/chemically induced; Gene Expression Regulation/genetics; Glial Fibrillary Acidic Protein/genetics; Glial Fibrillary Acidic Protein/metabolism; Humans; Interferon-gamma/genetics; Interferon-gamma/metabolism; Mice; Mice, Transgenic; Microfilament Proteins/metabolism; Myelin-Oligodendrocyte Glycoprotein/toxicity; Neuroglia/pathology; Neutrophil Infiltration/drug effects; Neutrophil Infiltration/genetics; Peptide Fragments/toxicity; Tumor Necrosis Factor-alpha/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Central Nervous System / Tumor Necrosis Factor-alpha / Encephalomyelitis, Autoimmune, Experimental / Macrophages Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2016 Document type: Article Affiliation country: United States Country of publication: United kingdom

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