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1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1.
Seya, Kazuhiko; Furukawa, Ken-Ichi; Chiyoya, Mari; Yu, Zaiqiang; Kikuchi, Haruhisa; Daitoku, Kazuyuki; Motomura, Shigeru; Murakami, Manabu; Oshima, Yoshiteru; Fukuda, Ikuo.
Affiliation
  • Seya K; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
  • Furukawa K; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Electronic address: furukawa@hirosaki-u.ac.jp.
  • Chiyoya M; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan; Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
  • Yu Z; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan; Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
  • Kikuchi H; Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan.
  • Daitoku K; Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
  • Motomura S; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
  • Murakami M; Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
  • Oshima Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan.
  • Fukuda I; Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
J Pharmacol Sci ; 131(1): 51-7, 2016 May.
Article in En | MEDLINE | ID: mdl-27165707
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aortic Valve / Aortic Valve Stenosis / Calcinosis / Quinolones / Sodium-Phosphate Cotransporter Proteins, Type III Limits: Aged / Humans / Middle aged Language: En Journal: J Pharmacol Sci Journal subject: FARMACOLOGIA Year: 2016 Document type: Article Affiliation country: Japan Country of publication: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aortic Valve / Aortic Valve Stenosis / Calcinosis / Quinolones / Sodium-Phosphate Cotransporter Proteins, Type III Limits: Aged / Humans / Middle aged Language: En Journal: J Pharmacol Sci Journal subject: FARMACOLOGIA Year: 2016 Document type: Article Affiliation country: Japan Country of publication: Japan