Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29.

Shekhar-Guturja, Tanvi; Tebung, Walters Aji; Mount, Harley; Liu, Ningning; Köhler, Julia R; Whiteway, Malcolm; Cowen, Leah E

Shekhar-Guturja, Tanvi; Tebung, Walters Aji; Mount, Harley; Liu, Ningning; Köhler, Julia R; Whiteway, Malcolm; Cowen, Leah E.

Affiliation

Shekhar-Guturja T; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Tebung WA; Department of Chemistry and Biochemistry, Concordia University, Montréal, Québec, Canada.
Mount H; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Liu N; Division of Infectious Diseases, Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Köhler JR; Division of Infectious Diseases, Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Whiteway M; Department of Biology, Concordia University, Montréal, Québec, Canada.
Cowen LE; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada leah.cowen@utoronto.ca.

Antimicrob Agents Chemother ; 60(12): 7468-7480, 2016 12.

Article in En | MEDLINE | ID: mdl-27736764

Subject(s)

ATP-Binding Cassette Transporters/antagonists & inhibitors; Antifungal Agents/pharmacology; Candida albicans/drug effects; Depsipeptides/pharmacology; Drug Resistance, Fungal/genetics; Fungal Proteins/antagonists & inhibitors; Gene Expression Regulation, Fungal; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Azoles/pharmacology; Base Sequence; Biological Products/pharmacology; Candida albicans/genetics; Candida albicans/growth & development; Candida albicans/metabolism; Drug Synergism; Fungal Proteins/genetics; Fungal Proteins/metabolism; Gene Expression Profiling; Microarray Analysis; Mutation; Signal Transduction; TOR Serine-Threonine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/genetics; TOR Serine-Threonine Kinases/metabolism; Transcription Factors/antagonists & inhibitors; Transcription Factors/genetics; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Candida albicans / Fungal Proteins / Gene Expression Regulation, Fungal / ATP-Binding Cassette Transporters / Drug Resistance, Fungal / Depsipeptides / Antifungal Agents Language: En Journal: Antimicrob Agents Chemother Year: 2016 Document type: Article Affiliation country: Canada Country of publication: United States

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