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From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer.
Zhang, Chun-Hui; Chen, Kai; Jiao, Yan; Li, Lin-Li; Li, Ya-Ping; Zhang, Rong-Jie; Zheng, Ming-Wu; Zhong, Lei; Huang, Shen-Zhen; Song, Chun-Li; Lin, Wan-Ting; Yang, Jiao; Xiang, Rong; Peng, Bing; Han, Jun-Hong; Lu, Guang-Wen; Wei, Yu-Quan; Yang, Sheng-Yong.
Affiliation
  • Zhang CH; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Chen K; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Jiao Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Li LL; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University , Chengdu, Sichuan 610041, China.
  • Li YP; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Zhang RJ; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Zheng MW; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Zhong L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Huang SZ; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Song CL; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University , Chengdu, Sichuan 610041, China.
  • Lin WT; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Yang J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Xiang R; Department of Clinical Medicine, School of Medicine, Nankai University , Tianjin 300071, China.
  • Peng B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Han JH; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Lu GW; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Wei YQ; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
  • Yang SY; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University , Sichuan 610041, China.
J Med Chem ; 59(21): 9788-9805, 2016 11 10.
Article in En | MEDLINE | ID: mdl-27739679
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Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Triple Negative Breast Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: China Country of publication: United States
Search on Google
Add to My VHL
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Triple Negative Breast Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Affiliation country: China Country of publication: United States